.RU

Chemical name : Talc (powder), containing no asbestos fibers - старонка 19


DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year:

49,193,1965
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 6250 ug/kg

SEX/DURATION : female 15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - skin and skin

appendages

REFERENCE :

AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.

(SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987. For

publisher

information, see BSTME2. Volume(issue)/page/year: 66,207,1977
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 6250 ug/kg

SEX/DURATION : multigenerations

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced

weight

gain)

REFERENCE :

AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.

(SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987. For

publisher

information, see BSTME2. Volume(issue)/page/year: 66,207,1977
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 50 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

per # females mated; # copulations per # estrus cycles)

Reproductive - Fertility - female fertility index (e.g. # females

pregnant

per # sperm positive females; # females pregnant per # females mated)

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

Volume(issue)/page/year: 122,88,1966
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 6250 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :

JPHYA7 Journal of Physiology. (Cambridge Univ. Press, 32 E. 57th St.,

New

York, NY 10022) V.1- 1878- Volume(issue)/page/year: 172,393,1964
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 1200 ug/kg

SEX/DURATION : female 9-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter;

measured

before birth)

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced

weight

gain)

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 3600 ug/kg

SEX/DURATION : female 9-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

Reproductive - Effects on Newborn - live birth index (measured after

birth)

Reproductive - Effects on Newborn - weaning or lactation index (e.g., #

alive at weaning per # alive at day 4)

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 3600 ug/kg

SEX/DURATION : female 9-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 50 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females

pregnant

per # sperm positive females; # females pregnant per # females mated)

REFERENCE :

JPHYA7 Journal of Physiology. (Cambridge Univ. Press, 32 E. 57th St.,

New

York, NY 10022) V.1- 1878- Volume(issue)/page/year: 172,393,1964
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intracerebral

SPECIES OBSERVED : Rodent - rat

DOSE : 10 ug/kg

SEX/DURATION : female 77 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

Reproductive - Maternal Effects - menstrual cycle changes or disorders

Reproductive - Maternal Effects - other effects

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

79,1135,1966
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 15 mg/kg

SEX/DURATION : female 15-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

REFERENCE :

JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,

Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-

Volume(issue)/page/year: 25,549,1962
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 250 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

Reproductive - Fertility - other measures of fertility

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

77,859,1965
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 500 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

77,859,1965
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 92 mg/kg

SEX/DURATION : male 23 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

per # females mated; # copulations per # estrus cycles)

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

29,409,1941
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - rat

DOSE : 10 ug/kg

SEX/DURATION : female 77 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

Reproductive - Maternal Effects - uterus, cervix, vagina

Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

79,1135,1966
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - rat

DOSE : 30 ug/kg

SEX/DURATION : female 77 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

79,1135,1966
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - rat

DOSE : 20 mg/kg

SEX/DURATION : male 5 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

per # females mated; # copulations per # estrus cycles)

REFERENCE :

ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd.

Saint-Germain,

F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year:

24(Suppl 3),1,1963
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - rat

DOSE : 3500 mg/kg

SEX/DURATION : female 10-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females

pregnant

per # sperm positive females; # females pregnant per # females mated)

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :

SAKNAH Soobshcheniia Akademii Nauk Gruzinskoi SSR. (V/O Mezhdunarodnaya

Kniga, 113095 Moscow, USSR) V.2- 1941- Volume(issue)/page/year:

64,737,1971
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Multiple routes

SPECIES OBSERVED : Rodent - rat

DOSE : 52500 ug/kg

SEX/DURATION : female 15 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects

REFERENCE :

SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H

St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:

181,770,1973
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 4 mg/kg

SEX/DURATION : male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

per # females mated; # copulations per # estrus cycles)

REFERENCE :

DEPBA5 Developmental Psychobiology. (John Wiley & Sons, Inc., 605 Third

Ave., New York, NY 10158) V.1- 1968- Volume(issue)/page/year:

12,231,1979
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 200 mg/kg

SEX/DURATION : female 12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - skin and skin

appendages

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

76,789,1965
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 40 mg/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females

pregnant

per # sperm positive females; # females pregnant per # females mated)

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

Volume(issue)/page/year: 85,673,1954
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 20 mg/kg

SEX/DURATION : female 10 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects

REFERENCE :

ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030,

Tokyo International, Tokyo, Japan) V.1- 1954-

Volume(issue)/page/year:

23,327,1976
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 190 mg/kg

SEX/DURATION : male 35 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's

gland,

accessory glands

REFERENCE :

JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,

Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-

Volume(issue)/page/year: 46,477,1970
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - mouse

DOSE : 15 mg/kg

SEX/DURATION : female 7-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

Reproductive - Specific Developmental Abnormalities - urogenital system

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced

weight

gain)

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - mouse

DOSE : 15 mg/kg

SEX/DURATION : female 7-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter;

measured

before birth)

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - mouse

DOSE : 240 mg/kg

SEX/DURATION : female 7-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - eye/ear

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intracerebral

SPECIES OBSERVED : Rodent - mouse

DOSE : 2 mg/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

Volume(issue)/page/year: 25,351,1982
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intracerebral

SPECIES OBSERVED : Rodent - mouse

DOSE : 2 mg/kg

SEX/DURATION : male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

Volume(issue)/page/year: 25,351,1982
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Mammal - dog

DOSE : 30 mg/kg

SEX/DURATION : male 60 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :

JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland

Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year:

27,327,1989
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rabbit

DOSE : 24500 ug/kg

SEX/DURATION : male 49 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

Reproductive - Fertility - male fertility index (e.g. # males

impregnating

females per # males exposed to fertile nonpregnant females)

REFERENCE :

EXCEDS Experimental and Clinical Edocrinology. (Johann Ambrosius Barth

Verlag, Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.) V.81- 1983-

Volume(issue)/page/year: 81,137,1983
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rabbit

DOSE : 1500 ug/kg

SEX/DURATION : female 27-29 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - postpartum

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Fertility - abortion

REFERENCE :

JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book

Depot,

POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-

Volume(issue)/page/year: 23,285,1970
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rabbit

DOSE : 10 mg/kg

SEX/DURATION : female 5 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :

ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,

NY

10003) V.1- 1906/08- Volume(issue)/page/year: 142,469,1962
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rabbit

DOSE : 500 ug/kg

SEX/DURATION : male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

per # females mated; # copulations per # estrus cycles)

REFERENCE :

JPHYA7 Journal of Physiology. (Cambridge Univ. Press, 32 E. 57th St.,

New

York, NY 10022) V.1- 1878- Volume(issue)/page/year: 181,568,1965
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rabbit

DOSE : 15750 ug/kg

SEX/DURATION : male 21 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

REFERENCE :

IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical

Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-

Volume(issue)/page/year: 71,375,1980
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Mammal - pig

DOSE : 142 mg/kg

SEX/DURATION : female 40-77 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

Reproductive - Effects on Newborn - delayed effects

REFERENCE :

ENDKAC Endokrinologie. (Leipzig, Ger. Dem. Rep.) V.1-80, 1928-82. For

publisher information, see EXCEDS. Volume(issue)/page/year: 63,161,1974
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Mammal - pig

DOSE : 140 mg/kg

SEX/DURATION : female 29-35 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :

BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309

W.

Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:

36,581,1987
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Mammal - pig

DOSE : 140 mg/kg

SEX/DURATION : female 39-45 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :

BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309

W.

Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:

36,581,1987
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 80 mg/kg

SEX/DURATION : female 30-45 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

per # females mated; # copulations per # estrus cycles)

Reproductive - Maternal Effects - menstrual cycle changes or disorders

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

JCPPAV Journal of Comparative and Physiological Psychology. (Washington,

DC) V.40-96, 1947-82. Volume(issue)/page/year: 57,166,1964
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 150 mg/kg

SEX/DURATION : female 28-58 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - delayed effects

REFERENCE :

HOBEAO Hormones and Behavior. (Academic Press, Inc., 1 E. First St.,

Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 6,139,1975
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 110 mg/kg

SEX/DURATION : female 50 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects

Reproductive - Fertility - male fertility index (e.g. # males

impregnating

females per # males exposed to fertile nonpregnant females)

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

72,429,1963
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 98 mg/kg

SEX/DURATION : female 24-68 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

Reproductive - Effects on Newborn - delayed effects

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

65,369,1959
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Mammal - horse, donkey

DOSE : 1575 ug/kg

SEX/DURATION : male 9 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's

gland,

accessory glands

REFERENCE :

JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309

W.

Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year:

51,1358,1980
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Mammal - cattle

DOSE : 5500 ug/kg

SEX/DURATION : female 40-60 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309

W.

Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year:

64,1858,1987
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Mammal - domestic

DOSE : 693 mg/kg

SEX/DURATION : female 40-60 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - endocrine system

Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :

JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309

W.

Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year:

68,4100,1990
TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Mammal - domestic

DOSE : 3045 ug/kg

SEX/DURATION : female 40-60 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced

weight

gain)

Reproductive - Effects on Newborn - biochemical and metabolic

Reproductive - Effects on Newborn - physical

REFERENCE :

JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309

W.

Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year:

65,1465,1987
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis

ROUTE OF EXPOSURE : Unreported

TEST SYSTEM : Fish - not otherwise specified

DOSE/DURATION : 500 ug

REFERENCE :

BEXBBO Biochemistry and Experimental Biology. (Padua, Italy) V.10-16,

1971/72-80. Suspended. Volume(issue)/page/year: 15,329,1980
TYPE OF TEST : Sperm Morphology

ROUTE OF EXPOSURE : Unreported

TEST SYSTEM : Fish - not otherwise specified

DOSE/DURATION : 500 ug

REFERENCE :

BEXBBO Biochemistry and Experimental Biology. (Padua, Italy) V.10-16,

1971/72-80. Suspended. Volume(issue)/page/year: 15,329,1980
TYPE OF TEST : DNA damage

TEST SYSTEM : Rodent - rat Liver

DOSE/DURATION : 300 umol/L

REFERENCE :

SinJF# Personal Communication from J.F. Sina, Merck Institute for

Therapeutic Research, West Point, PA 19486, Oct. 26, 1982

Volume(issue)/page/year: 26OCT1982
TYPE OF TEST : Sperm Morphology

ROUTE OF EXPOSURE : Subcutaneous

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 10 mg/kg

REFERENCE :

AMTUA3 Acta Medica Turcica. (Dr. Ayhan Okcuoglu, Cocuk Hastalikari

Klinigi,

c/o Ankara Univ., Tip Facultesi, Cebeci, Ankara, Turkey) V.1-10/11,

1948-58;

New series: V.1- 1964- Volume(issue)/page/year: 8,68,1971
TYPE OF TEST : Morphological transformation

TEST SYSTEM : Rodent - hamster Embryo

DOSE/DURATION : 1 mg/L

REFERENCE :

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,

Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-

Volume(issue)/page/year: 16,1329,1995
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

V.1- 1972- Volume(issue)/page/year: 21,519,1979
TOXICOLOGY REVIEW

CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment

Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-

Volume(issue)/page/year: 40,1825,1977
TOXICOLOGY REVIEW

ACRSAJ Advances in Cancer Research. (Academic Press, Inc., 465 S.

Lincoln

Dr., Troy, MO 63379) V.1- 1953- Volume(issue)/page/year: 1,173,1953
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X6098

No. of Facilities: 7 (estimated)

No. of Industries: 1

No. of Occupations: 2

No. of Employees: 628 (estimated)

No. of Female Employees: 314 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Sperm

morphology-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY

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